| 產(chǎn)品編號(hào) |
bs-0842R-HRP |
| 英文名稱1 |
Rabbit Anti-Myc tag/HRP Conjugated antibody
|
| 中文名稱 |
辣根過(guò)氧化物酶標(biāo)記的c-Myc tag標(biāo)簽抗體 |
| 別 名 |
avian myelocytomatosis viral oncogene homolog;
bHLHe39;
c-Myc;
C-Myc-Tag;
class E basic helix-loop-helix protein 39;
MRTL;
MYC;
Myc Epitope Tag;
myc proto-oncogene protein;
myc-related translation/localization regulatory factor;
oncogene c-Myc;
proto-oncogene c-Myc;
protooncogene homologous to myelocytomatosis virus;
transcription factor p64;
v-myc avian myelocytomatosis viral oncogene homolog;
v-myc myelocytomatosis viral oncogene homolog (avian);
MYC_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/1200元
購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 |
100ul
|
| 產(chǎn)品類型 |
標(biāo)簽抗體 |
| 研究領(lǐng)域 |
腫瘤 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞分化 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Recombinant protein
|
| 產(chǎn)品應(yīng)用 |
WB=1:10000-20000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
49kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated C-EQKLISEEDL (human Proto-oncogene c-Myc) |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Epitope tags are useful for the labeling and detection of proteins using
immunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast,insect and mammalian cell systems.
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2 (By similarity). Interacts with NO66.
Subcellular Location:
Nucleus, nucleoplasm. Nucleus, nucleolus.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Database links:
Entrez Gene: 4609 Human
Entrez Gene: 17869 Mouse
Entrez Gene: 24577 Rat
Omim: 190080 Human
SwissProt: P01106 Human
SwissProt: P01108 Mouse
SwissProt: P09416 Rat
Unigene: 202453 Human
Unigene: 2444 Mouse
Unigene: 12072 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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